Website created by Brian Ferrer, 2018
All website-related inquiries: please contact James Keck at jlkeck(at)wisc.edu
Welcome to the Keck Laboratory!
Research in the Keck lab examines the structural mechanisms that drive DNA replication, replication restart, recombination, and repair reactions. Successful execution of these pathways is essential in all cells, and defects in the proteins that facilitate genome maintenance reactions lead to genome instability, cell death, and disease. Our studies combine structural approaches with biochemical, genetic, and cellular biology methods to answer fundamental questions in genome biology.
Current major areas of interest include:
• Structural and cellular mechanisms that restart failed DNA replication processes
• Mechanisms that allow processing of forked and G-quadruplex nucleic acid structures
• Roles of protein interactions with single-stranded DNA-binding proteins